In your gut
Recirculation
Supportable dailyEstrobolome · β-glucuronidase
When gut bacteria reactivate more used estrogen, more of it returns to circulation instead of leaving the body.2
Shared by 1,400+ cliniciansThird-party testedVegan & allergen-freeMade in the USAWomen-owned
Hormone Balance Probiotic ES1
Estrogen dominance support that starts in your gut.
★★★★★"These really help all the symptoms." · Kristy, Verified Purchase
$35.99 $39.99
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Start Now →Heavy periods, sore breasts, bloating and mood swings in the week before your period are often signs that estrogen is running high relative to progesterone. Your gut decides how much used estrogen leaves your body and how much comes back. Hormone Balance ES1 is the daily probiotic built for the estrobolome, the gut bacteria that help your body clear estrogen.
- 7 clinically studied strains, 12 billion CFU, chosen for the gut–hormone axis
- Plus 265 mg Ahiflower® Omega 3·6·9 for a calm gut lining, no fish oil
- One small capsule a day. No hormones, no soy isolates, no stimulants
Free shipping on subscriptions · Cancel anytime · Shared by 1,400+ clinicians including OB/GYNs
Shared by 1,400+ cliniciansThird-party testedVegan & allergen-freeMade in the USAWomen-owned
Real Customer, Real Routine
See why she takes Hormone Balance every day.
One small capsule, seven clinically studied strains, built for the gut bacteria that help your body clear estrogen.
Start Now →Solving The Problem You're Experiencing
Your period got heavier. Your PMS got louder. Nobody told you why.
You are told it is stress, or age, or just a bad month. Very often it is a pattern: estrogen running high compared with progesterone, sometimes called estrogen dominance. It is not a single diagnosis, but a set of signs that tend to show up together, especially in the second half of your cycle. If several of these sound familiar, this page is for you.
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Most common
Heavy, long or painful periods
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Sore, swollen breasts before your period
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Bloating and water retention the week before
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Mood swings, irritability or anxiety before your period
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Weight settling on the hips and thighs
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Headaches that arrive with your cycle
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Spotting or shorter cycles
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Broken sleep in the second half of your cycle
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Fatigue and brain fog that come and go with your cycle
The Simple Explanation
How estrogen builds up, in three steps.
1
The balance tips toward estrogen
Estrogen and progesterone are meant to work as a pair. When ovulation is less regular, progesterone falls and estrogen is left running higher by comparison, even if estrogen itself is normal.4
2
Your body tries to clear the extra
Your liver packages used estrogen and sends it to your gut, so it can leave the body in stool. This is meant to be a one-way exit.1
3
Your gut can send it back
Some gut bacteria make an enzyme, β-glucuronidase, that unpacks used estrogen so it is reabsorbed instead of eliminated. More of that activity can mean more estrogen back in circulation.2,3
Steps one and two are hard to change day to day. Step three happens in your gut. Your gut bacteria help decide how much estrogen stays, which makes them one of the most practical places to start.
Where The Extra Estrogen Comes From
Four things that tip the balance.
In your cycle
Lower progesterone
Common in your 40sFewer ovulatory cycles
Progesterone is made after ovulation. Stress, age and perimenopause can mean fewer ovulatory cycles and less progesterone to balance estrogen.4
In your body
Body fat
A second sourceAromatase in fat tissue
Fat tissue contains aromatase, an enzyme that converts other hormones into estrogen, adding to what the ovaries make.5
Around you
Everyday exposures
Background loadAlcohol · low fiber · xenoestrogens
Low-fiber diets, regular alcohol and estrogen-like compounds in some plastics and personal care products add to the total your body has to manage.
The Estrobolome
Your gut doesn't just react to estrogen. It helps regulate it.
The estrobolome is the collection of gut bacteria that metabolize estrogen. A balanced estrobolome helps used estrogen leave the body. An imbalanced one can produce more β-glucuronidase, sending more estrogen back into circulation.1,2
Researchers describe this as a two-way axis: estrogen shapes the gut microbiome, and the gut microbiome shapes how much estrogen your body keeps.3 When estrogen is already running high, supporting the estrobolome is one of the few parts of the system you can work on every day.
The Gut–Hormone Connection
Your gut supports your hormones. Your probiotic should, too.
Most probiotics were designed for digestion alone. Estrogen balance depends on where your gut and your hormones meet, so the probiotic that supports it has to be built for both.
Why Hormone Balance
Seven strains chosen for the gut–hormone axis. Nothing else in it.
Hormone Balance ES1 is the daily probiotic built around the estrobolome, the gut bacteria that decide how much used estrogen is cleared and how much is reabsorbed. When that system is in balance, the monthly estrogen swing is smaller, digestion stays more regular and the gut lining stays calm. That is the gut–hormone connection, and supporting it every day is how you support healthy estrogen balance.
12 BILLION CFU
The 7-strain probiotic complex
Seven clinically studied strains selected for women's gut–hormone health, not a generic digestive blend repackaged for women. Lactobacillus species in particular have been studied for their role in estrogen metabolism and the gut–hormone axis.3
L. gasseri KABP™-064
L. rhamnosus IMC-501®
L. rhamnosus SP1
L. paracasei IMC-502®
L. brevis KABP™-052
P. acidilactici KABP™-021
L. plantarum KABP™-051
265 MG
Ahiflower® Omega 3·6·9
A plant-based seed oil rich in SDA, GLA and ALA, included to support a healthy inflammatory response in the gut lining. A calm gut lining is part of a healthy estrogen exit route.
No fish, no fillers, no aftertaste. Citrus-scented capsules, one a day, with or without food.
ZeroSynthetic hormones
ZeroSoy isolates
ZeroStimulants
ZeroTop-9 allergens
Formulated for every life stage: cycling years, perimenopause and postmenopause. Hormones fluctuate most in the late thirties and forties, which is exactly when the estrobolome's job matters most.
Watch
A closer look at Hormone Balance ES1.
Verified Reviews
What women say.
4.5
★★★★★
★★★★★
So glad I found these!!!
"This is my first time ever taking any supplement/ vitamins, and I will be 48 soon.
I have always had problems with sleep, and now that I'm in perimenopause it's been so much worse. I started these a month ago and for the first time in my life I am sleeping great!
The whole night through! I also feel better through out the day. The only regret I have is not starting these sooner!!!"
M · Verified Purchase · July 18, 2026 · 4 people found this helpful
★★★★★
They work
"Going though perimenopause and these really help all the symptoms"
Kristy · Verified Purchase · November 22, 2025 · 3 people found this helpful
Why Consistency Matters
Your gut responds first. Your cycle follows.
A probiotic works by establishing itself in your gut, and that is dose- and time-dependent. Estrogen balance runs on a second clock: your cycle. Most women judge the difference across two or three periods. Here is the arc most women describe.
Weeks 1–2
Digestion settles first
The gut is the fastest-responding piece. Less bloating, more regular days and a calmer stomach after meals.
Weeks 3–6
Your next cycle
One full cycle in is often when women first notice the week before their period feels different.
Weeks 7–12
The compounding window
By month three you have two or three cycles to compare. The gut–hormone support has had time to build, and the pattern is usually clear.
Consistency beats intensity. One capsule, every day. Missing a day will not undo your progress, but starting and stopping means the strains never get the chance to establish. Give it at least three cycles.
Proof
1,632 clinicians, including OB/GYNs, share it with patients.
"As an Integrative Reproductive Endocrinologist, I see the profound impact hormones have on people's lives every day. I am so excited there is now a probiotic that focuses on the foundational role the gut microbiome has on hormone regulation."
Dr. Lauren Rubal
Reproductive Endocrinologist
"So exciting to have an everyday probiotic that actually supports women's health. The gut has endocrine inputs and outputs that regulate so much, from menstrual cycles and weight to immune function and mood."
Dr. Francie Broghammer
Psychiatrist
Your Starting Point
Start today for $35.99 / month. Cancel anytime.
One capsule a day, 12 billion CFU, 265 mg Ahiflower®. One bottle ships now, a new one arrives every 30 days, and 15% off your first order applies automatically, no code to remember.
30-Day Start
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Monthly supply
1 bottle ships now
$35.99
/ month · was $39.99
- A fresh bottle every 30 days
- Never run out mid-cycle
- Free shipping, every order
- Skip, change frequency or cancel anytime
Try it without the risk
If Hormone Balance isn't right for you, contact us at hello@dailynouri.com within 30 days of delivery and we'll send a prepaid return label and refund you in full. Subscriptions have no minimum. Change your delivery frequency, skip a month, or cancel in two clicks from your account.
Before You Buy
Questions women ask us about estrogen dominance
What is estrogen dominance?+
It describes estrogen running high relative to progesterone. That can happen because estrogen is high, because progesterone is low, or both. It is not a formal diagnosis, but a common way to describe a set of symptoms that tend to appear together, especially before your period.
How do I know if I have it?+
Common signs include heavy or painful periods, breast tenderness, bloating and mood changes before your period. Hormone levels change through the month, so a single test rarely tells the whole story. Your clinician can look at your cycle, symptoms and timed lab work together.
What does my gut have to do with estrogen?+
Your liver sends used estrogen to your gut to be eliminated. Gut bacteria in the estrobolome can reactivate some of it with an enzyme called β-glucuronidase, so it is reabsorbed instead. The balance of those bacteria helps decide how much estrogen your body keeps.
How can a probiotic help?+
Hormone Balance ES1 supports the estrobolome, a balanced microbiome and a calm gut lining, the system your body uses to clear used estrogen. It does not contain hormones and is not a treatment for any condition.
Does it contain hormones, DIM or herbs?+
No. There are no hormones, hormone analogues, soy isolates or stimulants. It is seven probiotic strains plus plant-based Ahiflower® Omega 3·6·9, one capsule a day.
Can I take it with birth control or HRT?+
Many women take it alongside other care, but if you use hormonal birth control, HRT or any medication, check with your prescriber before starting.
How quickly will I notice a difference?+
Digestive changes often come first, within the first two weeks. Cycle-related changes take longer because you need a full cycle or two to compare. Give it at least three months of daily use before you judge it.
What else helps estrogen balance?+
Fiber helps used estrogen leave the body in stool, so vegetables, legumes, whole grains, flax and berries all support the same exit route. Cruciferous vegetables, regular movement, good sleep and less alcohol help too.
Do I need to refrigerate it?+
No. Store it at room temperature, out of direct sunlight. Take one capsule daily with water, with or without food, whatever makes it easiest to remember.
What if it doesn't work for me?+
Email hello@dailynouri.com within 30 days of delivery and we'll arrange a return and full refund. We'd rather you tell us it didn't work than quietly give up on it.
Hormone Balance Probiotic ES1
Support healthy estrogen balance.
One capsule a day.
Seven clinically studied strains built for the estrobolome. 12 billion CFU. Plant-based Ahiflower® Omega 3·6·9. No hormones, no soy isolates, no stimulants.
4.5★ from 1,400+ reviews
Shared by 1,400+ clinicians
Third-party tested
30-day returns
Start Now →
$35.99 / month, was $39.99 · 30-day start · Free shipping · Cancel anytime
References
- Plottel CS, Blaser MJ. Microbiome and Malignancy. Cell Host & Microbe. 2011;10(4):324–335.
- Ervin SM, Li H, Lim L, et al. Gut microbial β-glucuronidases reactivate estrogens as components of the estrobolome. Journal of Biological Chemistry. 2019;294(49):18586–18599.
- Baker JM, Al-Nakkash L, Herbst-Kralovetz MM. Estrogen-gut microbiome axis: Physiological and clinical implications. Maturitas. 2017;103:45–53.
- Santoro N. Perimenopause: from research to practice. Journal of Women's Health. 2016;25(4):332–339.
- Simpson ER. Sources of estrogen and their importance. Journal of Steroid Biochemistry and Molecular Biology. 2003;86(3–5):225–230.
Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Cited research describes studies of mechanisms and of individual probiotic strains, and is not a study of this finished product; probiotic effects are strain-specific. Individual results vary. Reviews reflect the experiences of individual customers and are not a guarantee of outcome. Always consult a qualified healthcare provider before starting a new supplement, especially if you are pregnant, breastfeeding, taking medication, or managing a medical condition.
