First and most often
Digestion
Week to weekBloating · gas · regularity
Hormone shifts change how your gut moves and how much water it holds, which is why bloating and regularity often change across the month.3
Shared by 1,400+ cliniciansThird-party testedVegan & allergen-freeMade in the USAWomen-owned
Hormone Balance Probiotic ES1
Your digestion can change with your hormones. Choose a probiotic with both in mind.
★★★★★"These really help all the symptoms." · Kristy, Verified Purchase
$35.99 $39.99
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Start today for $35.99 / month. 30-day start · Free shipping · Cancel anytime
Add to Cart →Bloating before your period, digestion that shifts week to week, cravings, breakouts and energy that comes and goes all trace back to the same place: the connection between your gut and your hormones. Hormone Balance ES1 is the daily probiotic built for the estrobolome, the gut bacteria that help regulate estrogen, so your gut and your hormones are supported together.
- 7 clinically studied strains, 12 billion CFU, chosen for the gut–hormone axis
- Plus 265 mg Ahiflower® Omega 3·6·9 for a calm gut lining, no fish oil
- One small capsule a day. No hormones, no soy isolates, no stimulants
Free shipping on subscriptions · Cancel anytime · Shared by 1,400+ clinicians including OB/GYNs
Shared by 1,400+ cliniciansThird-party testedVegan & allergen-freeMade in the USAWomen-owned
Real Customer, Real Routine
See why she takes Hormone Balance every day.
One small capsule, seven clinically studied strains, built for the gut bacteria that help keep your hormones in balance.
Add to Cart →Solving The Problem You're Experiencing
Your gut and your hormones change together. Most advice treats them separately.
You are told the bloating is something you ate, the breakouts are your skin and the low energy is stress. Very often they share one source: hormones that shift through your cycle and your life, and a gut that shifts with them. If several of these sound familiar, this page is for you.
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Most common
Digestion, bloating and gas that change week to week
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Breakouts that follow your cycle
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Weight that is harder to manage than it used to be
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PMS, cramps or mood swings before your period
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Cycles that feel less predictable
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Cravings that arrive with your cycle
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Energy that dips for days at a time
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Sleep that breaks in the second half of your cycle
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Brain fog that comes and goes
The Simple Explanation
How your gut and your hormones affect each other, in three steps.
1
Your hormones act on your gut
Estrogen and progesterone both affect how fast food moves through your gut and how much water it holds. As they rise and fall through your cycle, digestion and bloating often change with them.3
2
Your body clears used hormones through your gut
Your liver packages used estrogen and sends it to your gut, so it can leave the body in stool.1
3
Your gut bacteria help decide what stays
Some gut bacteria make an enzyme, β-glucuronidase, that unpacks used estrogen so it is reabsorbed instead of eliminated. Their balance helps decide how much estrogen stays in circulation.2,3
It works in both directions. Your hormones change your gut, and your gut helps regulate your hormones. That is the gut–hormone connection, and your gut is the part of it you can support every day.
Where The Gut–Hormone Connection Shows Up
Four places you are likely to feel it.
Every month
Your cycle
MonthlyPMS · cramps · mood
How much estrogen your body keeps or clears shapes how the week before your period feels.2
Over time
Skin, weight & energy
GradualBreakouts · cravings · energy dips
The gut–hormone axis is linked with metabolism, inflammation and skin, so changes here often build slowly rather than all at once.3
Through your life
Life stages
YearsCycling years · perimenopause · beyond
Hormones fluctuate most in the late thirties and forties, and the gut microbiome shifts across those years too.4
The Estrobolome
Your gut doesn't just react to estrogen. It helps regulate it.
The estrobolome is the collection of gut bacteria that metabolize estrogen. A balanced estrobolome helps used estrogen leave the body. An imbalanced one can produce more β-glucuronidase, sending more estrogen back into circulation.1,2
Researchers describe this as a two-way axis: estrogen shapes the gut microbiome, and the gut microbiome shapes how much estrogen your body keeps.3 Supporting the estrobolome is one of the few parts of hormone balance you can work on every day.
The Gut–Hormone Connection
Your gut supports your hormones. Your probiotic should, too.
Most probiotics were designed for digestion alone. Hormone balance depends on where your gut and your hormones meet, so the probiotic that supports it has to be built for both.
Why Hormone Balance
Seven strains chosen for the gut–hormone axis. Nothing else in it.
Hormone Balance ES1 is the daily probiotic built around the estrobolome, the gut bacteria that decide how much used estrogen is cleared and how much is reabsorbed. When that system is in balance, digestion stays more regular, the gut lining stays calm and your hormones have steadier support through the month. That is the gut–hormone connection, and supporting it every day is how you support healthy hormone balance.
12 BILLION CFU
The 7-strain probiotic complex
Seven clinically studied strains selected for women's gut–hormone health, not a generic digestive blend repackaged for women. Lactobacillus species in particular have been studied for their role in estrogen metabolism and the gut–hormone axis.3
L. gasseri KABP™-064
L. rhamnosus IMC-501®
L. rhamnosus SP1
L. paracasei IMC-502®
L. brevis KABP™-052
P. acidilactici KABP™-021
L. plantarum KABP™-051
265 MG
Ahiflower® Omega 3·6·9
A plant-based seed oil rich in SDA, GLA and ALA, included to support a healthy inflammatory response in the gut lining. A calm gut lining supports comfortable digestion and a healthy hormone exit route.
No fish, no fillers, no aftertaste. Citrus-scented capsules, one a day, with or without food.
ZeroSynthetic hormones
ZeroSoy isolates
ZeroStimulants
ZeroTop-9 allergens
Formulated for every life stage: cycling years, perimenopause and postmenopause. Hormones fluctuate most in the late thirties and forties, which is exactly when the estrobolome's job matters most.
Watch
A closer look at Hormone Balance ES1.
Verified Reviews
What women say.
4.5
★★★★★
★★★★★
So glad I found these!!!
"This is my first time ever taking any supplement/ vitamins, and I will be 48 soon.
I have always had problems with sleep, and now that I'm in perimenopause it's been so much worse. I started these a month ago and for the first time in my life I am sleeping great!
The whole night through! I also feel better through out the day. The only regret I have is not starting these sooner!!!"
M · Verified Purchase · July 18, 2026 · 4 people found this helpful
★★★★★
They work
"Going though perimenopause and these really help all the symptoms"
Kristy · Verified Purchase · November 22, 2025 · 3 people found this helpful
Why Consistency Matters
Your gut responds first. Your hormones follow.
A probiotic works by establishing itself in your gut, and that is dose- and time-dependent. Hormone balance runs on a second clock: your cycle. Most women judge the difference across two or three periods. Here is the arc most women describe.
Weeks 1–2
Digestion settles first
The gut is the fastest-responding piece. Less bloating, more regular days and a calmer stomach after meals.
Weeks 3–6
Your next cycle
One full cycle in is often when women first notice the week before their period feels different.
Weeks 7–12
The compounding window
By month three you have two or three cycles to compare. The gut–hormone support has had time to build, and the pattern is usually clear.
Consistency beats intensity. One capsule, every day. Missing a day will not undo your progress, but starting and stopping means the strains never get the chance to establish. Give it at least three cycles.
Proof
1,632 clinicians, including OB/GYNs, share it with patients.
"As an Integrative Reproductive Endocrinologist, I see the profound impact hormones have on people's lives every day. I am so excited there is now a probiotic that focuses on the foundational role the gut microbiome has on hormone regulation."
Dr. Lauren Rubal
Reproductive Endocrinologist
"So exciting to have an everyday probiotic that actually supports women's health. The gut has endocrine inputs and outputs that regulate so much, from menstrual cycles and weight to immune function and mood."
Dr. Francie Broghammer
Psychiatrist
Your Starting Point
Start today for $35.99 / month. Cancel anytime.
One capsule a day, 12 billion CFU, 265 mg Ahiflower®. One bottle ships now, a new one arrives every 30 days, and 15% off your first order applies automatically, no code to remember.
30-Day Start
Free shipping
Monthly supply
1 bottle ships now
$35.99
/ month · was $39.99
- A fresh bottle every 30 days
- Never run out mid-cycle
- Free shipping, every order
- Skip, change frequency or cancel anytime
Try it without the risk
If Hormone Balance isn't right for you, contact us at hello@dailynouri.com within 30 days of delivery and we'll send a prepaid return label and refund you in full. Subscriptions have no minimum. Change your delivery frequency, skip a month, or cancel in two clicks from your account.
Before You Buy
Questions women ask us about gut and hormone health
What is the gut–hormone connection?+
Your hormones affect how your gut works, and your gut helps regulate your hormones. Estrogen and progesterone change digestion and bloating through your cycle, and gut bacteria in the estrobolome help decide how much used estrogen your body clears or keeps.
Why does my digestion change through my cycle?+
Estrogen and progesterone both act on the gut. As they rise and fall, they change how quickly food moves through and how much water your gut holds, which is why bloating, gas and regularity often shift week to week.
What is the estrobolome?+
It is the collection of gut bacteria that metabolize estrogen. Some of them make an enzyme called β-glucuronidase that can reactivate used estrogen so it is reabsorbed instead of eliminated. Their balance is part of how your body regulates estrogen.
How is this different from a regular probiotic?+
Most probiotics are built for digestion alone. Hormone Balance ES1 uses seven strains chosen for the gut–hormone axis, plus Ahiflower® Omega 3·6·9 for a calm gut lining, so it supports digestion and the estrobolome together.
Does it contain hormones or herbs?+
No. There are no hormones, hormone analogues, soy isolates or stimulants. It is seven probiotic strains plus plant-based Ahiflower® Omega 3·6·9, one capsule a day.
Is it right for my age or life stage?+
It is formulated for every stage, from cycling years through perimenopause and postmenopause. The estrobolome keeps working at every stage, and its job matters most when hormones are fluctuating.
Can I take it with birth control or HRT?+
Many women take it alongside other care, but if you use hormonal birth control, HRT or any medication, check with your prescriber before starting.
How quickly will I notice a difference?+
Digestive changes often come first, within the first two weeks. Cycle-related changes take longer because you need a full cycle or two to compare. Give it at least three months of daily use before you judge it.
What else supports gut and hormone health?+
Fiber feeds healthy gut bacteria and helps used estrogen leave the body, so vegetables, legumes, whole grains, flax and berries all help. Regular movement, good sleep and less alcohol support the same system.
Do I need to refrigerate it?+
No. Store it at room temperature, out of direct sunlight. Take one capsule daily with water, with or without food, whatever makes it easiest to remember.
What if it doesn't work for me?+
Email hello@dailynouri.com within 30 days of delivery and we'll arrange a return and full refund. We'd rather you tell us it didn't work than quietly give up on it.
Hormone Balance Probiotic ES1
Support your gut and your hormones.
One capsule a day.
Seven clinically studied strains built for the estrobolome. 12 billion CFU. Plant-based Ahiflower® Omega 3·6·9. No hormones, no soy isolates, no stimulants.
4.5★ from 1,400+ reviews
Shared by 1,400+ clinicians
Third-party tested
30-day returns
Add to Cart →
$35.99 / month, was $39.99 · 30-day start · Free shipping · Cancel anytime
References
- Plottel CS, Blaser MJ. Microbiome and Malignancy. Cell Host & Microbe. 2011;10(4):324–335.
- Ervin SM, Li H, Lim L, et al. Gut microbial β-glucuronidases reactivate estrogens as components of the estrobolome. Journal of Biological Chemistry. 2019;294(49):18586–18599.
- Baker JM, Al-Nakkash L, Herbst-Kralovetz MM. Estrogen-gut microbiome axis: Physiological and clinical implications. Maturitas. 2017;103:45–53.
- Santoro N. Perimenopause: from research to practice. Journal of Women's Health. 2016;25(4):332–339.
Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Cited research describes studies of mechanisms and of individual probiotic strains, and is not a study of this finished product; probiotic effects are strain-specific. Individual results vary. Reviews reflect the experiences of individual customers and are not a guarantee of outcome. Always consult a qualified healthcare provider before starting a new supplement, especially if you are pregnant, breastfeeding, taking medication, or managing a medical condition.
