Your gut decides how much estrogen stays in your body.
Hormone Balance is a once-daily probiotic built for the estrobolome — the community of gut bacteria that metabolize and regulate your estrogen. Support it at the root, and you support your cycle, skin, mood, and menopause transition.
The first and only clinically supported probiotic built to support the estrobolome.
Endocrinologist and OB/GYN recommended — grounded in the science of the gut–hormone connection, not in wellness trends. Hormone Balance targets estrogen metabolism at its source: your gut.
including OB/GYNs, share this on FrontrowMD — without compensation.
Dr. Lauren Rubal, MD
Lauren Rubal, MD, is a USC-trained Reproductive Endocrinology & Infertility physician with a boutique practice in Orange County, CA. Her unique approach focuses on fertility, recurrent miscarriage, painful, irregular, or heavy cycles, and menopause using an integrative lens.
An integrative view of women's hormones starts where so much of the body's regulation begins — the gut.
The gut microbiome doesn't just affect digestion — it regulates estrogen.
A specific set of microbes — the estrobolome — controls whether estrogen is reabsorbed back into your bloodstream or safely eliminated. When that balance tips, your hormones feel it.
A hidden system that helps run your hormones.
Tucked inside your gut is a collection of bacteria with a remarkable job: metabolizing estrogen. Researchers call it the estrobolome — and it acts like a thermostat for the estrogen circulating through your body.
These microbes produce an enzyme called beta-glucuronidase, which can reactivate estrogen that your body had packaged for removal. Too much activity, and estrogen builds back up. Too little, and levels can drop. A balanced estrobolome keeps that dial steady.
The collection of gut bacteria capable of metabolizing and modulating the body's circulating estrogen.
How estrogen moves through you.
Three steps decide whether used estrogen leaves your body or circulates again — and your gut sits right in the middle.
Estrogen is processed
Your liver deactivates used estrogen and sends it to the gut, packaged for elimination.
Bacteria intervene
Certain gut microbes release beta-glucuronidase, an enzyme that can reactivate that estrogen.
Balance decides
A balanced estrobolome keeps reactivation in check — so estrogen is eliminated, not recirculated in excess.
Signs your estrobolome may need support.
When the gut–hormone connection is off, the symptoms often look like the ones written off as "just hormones."
Irregular or heavy cycles
Periods that shift, intensify, or grow unpredictable.
Stubborn PMS
Bloating, tenderness, and mood dips that won't let up.
Hard-to-shift weight
Changes around the midsection that resist your usual routine.
Skin breakouts
Hormonal flare-ups that track with your cycle.
Mood swings & low energy
Irritability and fatigue that come and go with hormones.
A rocky menopause transition
Perimenopause symptoms that feel harder than they should.
Symptoms have many causes. Hormone Balance is designed to support the gut–hormone connection — it is not a diagnosis or treatment. Talk with your provider about what you're experiencing.
Clinically studied strains, once a day.
Hormone Balance delivers targeted probiotic strains selected to support a healthy female microbiome and the estrogen metabolism that depends on it — in a single small capsule.
A capsule, protected inside a capsule.
Most probiotics are broken down by stomach acid before they ever reach the gut. Hormone Balance seals its strains inside a second, inner capsule — a protective shell that carries them past the stomach and releases them deeper down, where the estrobolome actually lives.
Seven clinically studied strains.
Hormone Balance is not a generic probiotic. Every strain was chosen for an evidence-backed role in the female gut microbiome and estrogen metabolism — delivered at 12 billion CFU in one daily capsule.
Lactobacillus gasseri KABP™-064
Women's healthA women's-microbiome strain studied for vaginal and metabolic balance that complements estrogen regulation through the gut.
L. rhamnosus IMC-501®
RegularityHalf of the SYNBIO® pair, studied to improve bowel habits and microbiota balance — the regularity that helps estrogen leave the body.
L. paracasei IMC-502®
AntimicrobialThe SYNBIO® partner strain — stabilizes intestinal microbiota and produces bacteriocins active against bacterial and Candida pathogens.
L. brevis KABP™-052
MenopausePart of a women's-health trio studied to help offset the estrogen decline of menopause and support healthy mucosal colonization.
P. acidilactici KABP™-021
Barrier · ImmuneSynthesizes poly-phosphate that supports intestinal barrier integrity, and acetate that balances the gut's inflammatory response.
L. plantarum KABP™-051
Gut barrierA robust, well-characterized strain studied for gut colonization and bioactive-compound production within the women's-health trio.
L. rhamnosus SP1
Gut–skinActs on the gut–skin axis — in a 12-week placebo-controlled trial it improved adult hormonal acne and normalized skin gene expression.
Strain roles summarize published research on each species and are not specific clinical claims for this product. These statements have not been evaluated by the FDA.
Three bottles. Ninety days. One reset.
Rebalancing the estrobolome takes consistency. The reset gives you a full three-month supply — the window your microbiome needs to shift — at the best value.
Introduce targeted strains and begin seeding a healthier female microbiome.
Support consistent estrogen metabolism as the estrobolome stabilizes.
Reinforce the foundation you've built and keep the gut–hormone connection steady.
Hormone Balance Probiotic
The estrobolome, answered.
What exactly is the estrobolome?+
It's the collection of gut bacteria capable of metabolizing estrogen. Through an enzyme called beta-glucuronidase, these microbes influence whether estrogen is reabsorbed into circulation or eliminated — making the gut a key regulator of your hormones.
How does Hormone Balance support my hormones?+
It delivers targeted, clinically studied probiotic strains selected for the female microbiome to support a balanced estrobolome and healthy estrogen metabolism — taken as one small capsule, once daily.
Why 90 days? How long until I notice a difference?+
The microbiome shifts gradually. Ninety days of consistent daily use gives the estrobolome the window it needs to rebalance — which is why the 3-bottle reset is the way most women start. Individual experiences vary.
Is it safe to take every day?+
Hormone Balance is a daily dietary supplement. As with any supplement, if you are pregnant, nursing, taking medication, or managing a medical condition, talk with your healthcare provider before starting.
What's included in the $79.89 reset?+
Three bottles of Hormone Balance Probiotic — a full 90-day supply at $79.89 ($26.63 per bottle), the best value for completing a full estrobolome reset.
Start where your hormones actually start.
Support the estrobolome with a full 90-day reset, and give the gut–hormone connection the consistency it needs.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Information on this page is educational and not a substitute for medical advice.