Hormone Balance Probiotic ES1
★★★★★ 4.5 · 1,400+ verified reviews

The support system your hormones have been waiting for.

Hormone Balance Probiotic ES1
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★★★★★ 4.5 · 1,400+ verified reviews

Your gut and hormones are intricately connected through what is called the estrobolome. Hormone Balance ES1 is the only daily probiotic built to support that system.

  • 7 clinically studied strains, 12 billion CFU, chosen for the gut–hormone axis
  • Plus 265 mg Ahiflower® Omega 3·6·9: plant-based, no fish oil burps
  • One small capsule a day. No hormones, no soy isolates, no stimulants

Free shipping on subscriptions · Cancel anytime · Shared by 1,400+ clinicians including OB/GYNs

Daily Nouri Hormone Balance Probiotic bottle with citrus and capsules
Shared by 1,400+ clinicians
Third-party tested
Vegan & allergen-free
Made in the USA
Women-owned
Verified Reviews

What women say after the first bottle.

4.5
★★★★★
Based on 1,400+ verified reviews
★★★★★

On my second bottle!

"It wasnt until I stopped taking these that I noticed a difference. My appetite came back stronger, my moods started changing. I noticed it had been weeks since I had taken these since I ran out. I bought another bottle. You won't really notice any difference until you stop and all your symptoms come back! Would recommend this if you have mood swings for sure! This is my second bottle and will continue to purchase!"

Jennifer · Verified Purchase · July 30, 2026
★★★★★

So glad I found these!!!

"This is my first time ever taking any supplement/ vitamins, and I will be 48 soon. I have always had problems with sleep, and now that I'm in perimenopause it's been so much worse. I started these a month ago and for the first time in my life I am sleeping great! The whole night through! I also feel better through out the day. The only regret I have is not starting these sooner!!!"

M · Verified Purchase · July 18, 2026
★★★★★

Every women needs this

"Good product. Makes me feel energized whenever I take it"

Sophie Kange · Verified Purchase · July 17, 2026
Start Here

If any of these symptoms sound like you, read on.

Most women are told this is just part of being a woman. It isn't. These are the everyday signals of a gut–hormone system that's working against you instead of with you.

PMS that's gotten noticeably worse with age

Bloating that spikes in the week before your period

Periods that are heavier or longer than they used to be

Mood swings and anxiety that track with your cycle

Headaches that arrive on schedule every month

Sleep that breaks at 3am, night sweats, hot flashes

Brain fog, flat energy, and libido that disappeared

Constipation or IBS-like patterns that worsen premenstrually

These cluster together for a reason. They share an upstream cause almost nobody addresses, and it's one of the most responsive to daily, consistent support.

The Root Cause

Your gut bacteria are an estrogen control valve.

Gut microbiome science imagery

The estrobolome is the group of gut bacteria that metabolize estrogen. First named in peer-reviewed science in 2011, it decides how much used estrogen gets recirculated back into your body versus cleanly excreted.1

1

Your liver tags used estrogen for removal

Once estrogen has done its job, the liver marks it "spent" through a process called glucuronidation and sends it to the gut for elimination.

2

Your gut bacteria decide what happens next

Bacteria in the estrobolome produce an enzyme called beta-glucuronidase, which can cut that tag right back off, reactivating the estrogen and sending it back into circulation.2

3

Balance is everything

Too much recirculation and estrogen builds. Too little and it drops too fast. Either way, the symptoms above are what it feels like from the inside.3

Estrogen metabolism and the estrobolome

Modern life is hostile to this system: low fiber, chronic stress, alcohol, antibiotics, poor sleep, and constant xenoestrogen exposure all push it out of balance. You don't need to be perfect on all of them. You need a consistent daily counter-balance.

Watch

A closer look at Hormone Balance ES1.

The Formula

Built for the gut–hormone axis. Nothing else in it.

Most "hormone" supplements push estrogen up or down with botanicals or hormone analogues. Hormone Balance ES1 does something different. It nourishes the bacterial system your hormones already depend on.

12 BILLION CFU

The 7-strain probiotic complex

Seven clinically studied strains selected specifically for women's gut–hormone health, not a generic digestive blend repackaged for women.

L. gasseri KABP™-064 L. rhamnosus IMC-501® L. rhamnosus SP1 L. paracasei IMC-502® L. brevis KABP™-052 P. acidilactici KABP™-021 L. plantarum KABP™-051
265 MG

Ahiflower® Omega 3·6·9

A plant-based seed oil rich in SDA, GLA, and ALA, included to support a healthy inflammatory response in the gut, because a compromised intestinal barrier disrupts estrogen metabolism.

No fish, no fillers, no aftertaste. Citrus-scented capsules, one a day, with or without food.

ZeroSynthetic hormones
ZeroSoy isolates
ZeroStimulants
ZeroTop-9 allergens
What to Expect

Probiotics reward consistency, not intensity.

Colonization is dose- and time-dependent. Here's the arc most women describe.

Days 1–14

Digestion settles first

The gut is the fastest-responding piece. Many women notice less bloating and more regular, comfortable digestion in the first two weeks.

Days 15–45

Your cycle starts to shift

One to two full cycles in is where the premenstrual week often changes: calmer mood, less breast tenderness, less of the pre-period crash.

Days 46–90

The compounding window

This is where it adds up: steadier energy, clearer head, better sleep, and the sense that your body is finally on your side again.

Give it 90 days. That's why our best-value option is a full 90-day supply. It's the length of time the research and our customers both point to.

Proof

1,400+ women have already made the switch.

4.5
★★★★★
Based on 1,400+ verified reviews
★★★★★

"Three months in, my cycle feels more predictable than it has in years, and I actually look forward to taking it."

Maya R. · 4-month subscriber
★★★★★

"It's one small capsule a day: easy to remember, easy on my stomach, and I genuinely feel the difference."

Priya S. · 7-month subscriber
★★★★★

"I've tried a dozen probiotics. This is the first one built around women's hormones, and it shows."

Danielle K. · 2-month subscriber

And 1,400+ clinicians, including OB/GYNs, share it with patients.

"As an Integrative Reproductive Endocrinologist, I see the profound impact hormones have on people's lives every day. I am so excited there is now a probiotic that focuses on the foundational role the gut microbiome has on hormone regulation."

Dr. Lauren Rubal
Reproductive Endocrinologist

"So exciting to have an everyday probiotic that actually supports women's health. The gut has endocrine inputs and outputs that regulate so much, from menstrual cycles and weight to immune function and mood."

Dr. Francie Broghammer
Psychiatrist
Choose Your Supply

Start today. Cancel anytime.

Every option is the same formula: one capsule, 12 billion CFU, 265 mg Ahiflower®. The only difference is how long you commit and how much you save. 15% off your first order applies automatically to all three, no code to remember.

Most Flexible

Monthly

1 bottle ships now
$29.49
today

Renews at $34.69 monthly · $1.16 per day

  • Try it for one full cycle
  • Free shipping, every order
  • Change frequency, skip or cancel anytime
Lowest Price

6-month supply

All 6 bottles ship together
$141.53
today

Renews at $166.50 every 6 months · $0.93 per day

Save 20% vs monthly
  • Cheapest per-day price we offer
  • Six months, one decision
  • Free shipping, every order

Also available on Amazon. Prices shown in USD.

Try it without the risk

If Hormone Balance isn't right for you, contact us at hello@dailynouri.com within 30 days of delivery and we'll send a prepaid return label and refund you in full. Subscriptions have no minimum. Change your delivery frequency, skip a month, or cancel in two clicks from your account.

Before You Buy

Questions women ask us most

How long until I notice something?+

Digestive changes often come first, within the first two weeks. Cycle-related changes usually take one to two full cycles, roughly 30 to 60 days. Most women who describe a real shift have been taking it consistently for 90 days. It works on the microbiome, and microbiomes change on their own timeline.

How is this different from the probiotic I already take?+

Most probiotics are built for digestion, with strains chosen for gut comfort. Hormone Balance ES1 uses seven strains selected for the gut–hormone axis specifically, and pairs them with Ahiflower® Omega 3·6·9 for the intestinal barrier. It's a different job, so it's a different formula.

Does it contain hormones or anything hormone-like?+

No. There are no synthetic hormones, no hormone analogues, no soy isolates, and no stimulants. It doesn't push your estrogen up or down. It supports the bacteria that regulate how your body clears it.

Can I take it in perimenopause?+

Yes. Perimenopause is when many women feel the difference most. Cycles get less predictable, sleep breaks up, and the premenstrual week hits harder, all while the estrobolome's role in clearing estrogen keeps mattering. Hormone Balance ES1 is built for the cycling and perimenopausal years.

Do I need to refrigerate it?+

No. Store it at room temperature, out of direct sunlight. Take one capsule daily with water, with or without food, whatever makes it easiest to remember.

Is it safe with my medication, or if I'm pregnant?+

It's hormone-free, vegan, third-party tested, and free from nine major allergens. That said, if you're pregnant, breastfeeding, or taking medication, talk to your healthcare provider before starting, as you should with any new supplement.

Can I cancel my subscription?+

Anytime, from your account, in two clicks. There's no minimum number of orders. You can also skip a shipment or change how often it arrives if you're moving through a bottle slower than expected.

What if it doesn't work for me?+

Email hello@dailynouri.com within 30 days of delivery and we'll arrange a return and full refund. We'd rather you tell us it didn't work than quietly give up on it.

Hormone Balance Probiotic ES1

One capsule a day.
Ninety days to feel the difference.

Seven clinically studied strains. 12 billion CFU. Plant-based Ahiflower® Omega 3·6·9. Built for women from cycling years through post-menopause.

4.5★ from 1,400+ reviews Shared by 1,400+ clinicians Third-party tested 30-day returns

Save 15% on your first order · Free shipping on subscriptions · Cancel anytime

References

  1. Plottel CS, Blaser MJ. Microbiome and Malignancy. Cell Host & Microbe. 2011;10(4):324–335.
  2. Ervin SM, Li H, Lim L, et al. Gut microbial β-glucuronidases reactivate estrogens as components of the estrobolome. Journal of Biological Chemistry. 2019;294(49):18586–18599.
  3. Baker JM, Al-Nakkash L, Herbst-Kralovetz MM. Estrogen-gut microbiome axis: Physiological and clinical implications. Maturitas. 2017;103:45–53.

Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results vary. Reviews reflect the experiences of individual customers and are not a guarantee of outcome. Always consult a qualified healthcare provider before starting a new supplement, especially if you are pregnant, breastfeeding, taking medication, or managing a medical condition.