A probiotic built for menopause symptoms.
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As your ovaries make less estrogen, your body leans harder on what's left. Gut bacteria called the estrobolome govern how much of that remaining estrogen gets recirculated versus cleared, and even help convert plant compounds into forms your body can use. Hormone Balance ES1 is the daily probiotic built to support that system through the transition.
- Works on the estrobolome, the gut bacteria that keep regulating estrogen as your ovaries slow down
- 7 clinically studied strains, 12 billion CFU, for the gut–hormone axis
- Plus 265 mg Ahiflower® Omega 3·6·9, plant-based, no fish oil burps
- One small capsule a day. No hormones, no soy isolates, no stimulants
Free shipping on subscriptions · Cancel anytime · Shared by 1,400+ clinicians including OB/GYNs
What women in menopause are saying.
This is a great product to help your menopause symptoms!
"I like how I feel while using these supplements. Menopause is NO JOKE HARD! So I decided to do something about it, and came across someone who recommended this product, so I ordered it. Midlife problems seems to be better for me already, I'm six days in on using this product!"
This WORKS
"Absolutely love these as there are no more nights of hormonal horror. The citrus scent is welcoming. I do see an advanced improvement in three weeks. Wife is 55 yo and will not go without these as they DO work."
Life-changing
"This product is a game changer. Would buy again."
Six days in and already different
"I've read the other reviews and it's reassuring to see the same pattern: a noticeable difference inside the first few weeks, not months. That matches my own experience so far."
If these menopause symptoms sound familiar, read on.
Perimenopause and menopause bring on a cluster of changes that feel disconnected, but they are not random. Most are downstream of the same hormonal shift, and that shift is one your gut has a hand in regulating.
Hot flashes that arrive without warning, day or night
Night sweats that break your sleep and soak through the sheets
Sleep that breaks at 2 or 3am and won't restart
Mood swings, irritability or anxiety that feel unlike you
Brain fog and losing your train of thought mid-sentence
Weight gain around the middle, even with no change in diet
Vaginal dryness or discomfort
Joint aches and stiffness that showed up out of nowhere
Periods that have become irregular or unpredictable
Low libido
Bloating or digestive changes that are new for you
These cluster together for a reason. They are downstream of a hormonal shift your gut helps regulate, and that system is one of the few upstream causes you can support daily.
In menopause, your ovaries slow down. Your gut becomes more important, not less.
During the menopause transition, ovarian estrogen production declines sharply. It is tempting to think that means the gut matters less. The opposite is true: with less estrogen being made, what your body does with the estrogen it still has, and with the plant compounds you eat, carries more of the load.
The estrobolome is the group of gut bacteria that metabolize estrogen. First named in peer-reviewed science in 2011, it decides how much used estrogen gets recirculated back into your body versus cleanly excreted.1
Ovarian estrogen production declines
This is the transition itself. It doesn't happen overnight; it unfolds over several years, which is why symptoms can feel inconsistent before they feel constant.
Peripheral tissue and gut bacteria take on more of the job
With less coming from the ovaries, fat tissue and the estrobolome play a larger relative role in the estrogen still circulating in your body, through production, recirculation and clearance.2,3
Your gut also decides what to do with plant compounds
Specific gut bacteria convert soy isoflavones into a compound called equol. Whether you produce it depends on your microbiome, not just your diet.4
This is also why the timeline can feel long. Research following women through the transition found that hot flashes and night sweats last a median of more than seven years for many women, often continuing well past the final period.6 A system working on that timescale needs daily, consistent support, not a two-week trial.
The equol connection: one reason some women feel hot flashes more than others.
What equol is
Equol is a compound your gut bacteria make by fermenting isoflavones from soy and other plants. It has a mild, estrogen-like structure. Not everyone's microbiome can make it: research estimates roughly a third to half of people in Western populations are "equol producers," and the rest are not, regardless of how much soy they eat.4
Why it may matter for symptoms
A systematic review and meta-analysis published in JAMA found that soy isoflavones were associated with a modest reduction in hot flash frequency across trials, an effect that plausibly depends on whether a woman's gut can convert those isoflavones into equol in the first place.5
None of this means eating more soy is a fix on its own. It means the bacteria capable of making that conversion, and of regulating estrogen more broadly, are worth supporting directly. That is the premise behind the estrobolome-targeted strains in this formula.
This is not a hormone. Nothing in this formula adds estrogen or mimics it directly. It supports the bacterial systems that determine how your body handles the estrogen and plant compounds you already have.
Built for the gut–hormone axis throughout menopause. Nothing else in it.
Most menopause supplements lean on herbal blends or bioidentical hormones. Hormone Balance ES1 does something different for menopause: it supports the bacterial system your hormones already depend on, at the stage of life where that system does more of the work.
The 7-strain probiotic complex
Seven clinically studied strains selected for the gut–hormone axis, including L. gasseri, one of the most researched species for abdominal fat and metabolic health in adults.9
Ahiflower® Omega 3·6·9
A plant-based seed oil rich in SDA, GLA and ALA, included to support a healthy inflammatory response in the gut. Barrier integrity matters here because it underlies how well your gut regulates hormones and inflammation as estrogen shifts.3
No fish, no fillers, no aftertaste. Citrus-scented capsules, one a day, with or without food.
A closer look at Hormone Balance ES1.
Give your menopause transition the same time it took to build.
Colonization is dose- and time-dependent, and menopausal symptoms move on their own long timeline on top of that. Nothing about this is a two-week fix. Here is the arc most women describe.
Digestion settles first
The gut responds fastest. Many women notice less bloating and more regular digestion within the first two weeks, before anything else shifts.
Sleep and mood often steady
This is where women most often tell us they notice fewer night sweats, steadier mood, and a sleep pattern that breaks less often.
The compounding window
Steadier energy, clearer head, and the sense that your body is responding rather than working against you. This is the window we ask you to judge it by.
Give it 90 days. Hot flashes and night sweats can persist for years once they start.6 That long runway is exactly why our best-value option is a full 90-day supply.
1,400+ clinicians, including OB/GYNs, share it with patients.
"As an Integrative Reproductive Endocrinologist, I see the profound impact hormones have on people's lives every day. I am so excited there is now a probiotic that focuses on the foundational role the gut microbiome has on hormone regulation."
"So exciting to have an everyday probiotic that actually supports women's health. The gut has endocrine inputs and outputs that regulate so much, from menstrual cycles and weight to immune function and mood."
Start supporting your menopause today. Cancel anytime.
Every option is the same formula: one capsule, 12 billion CFU, 265 mg Ahiflower®. The only difference is how long you commit and how much you save. 15% off your first order applies automatically to all three, no code to remember.
Monthly
- Try it for a full month
- Free shipping, every order
- Change frequency, skip or cancel anytime
3-month supply
- The full window most women need to judge it
- Never run out mid-transition
- Free shipping, every order
- Skip or cancel anytime
6-month supply
- Lowest per-day price we offer
- Six months, one decision
- Free shipping, every order
Also available on Amazon. Prices shown at checkout in USD.
Try it without the risk
If Hormone Balance isn't right for you, contact us at hello@dailynouri.com within 30 days of delivery and we'll send a prepaid return label and refund you in full. Subscriptions have no minimum. Change your delivery frequency, skip a month, or cancel in two clicks from your account.
Menopause questions women ask us most
How long until I notice a difference?+
Digestion often settles first, within the first two weeks. Sleep and mood changes usually take three to six weeks. The full effect builds over 90 days, which is also roughly how long research suggests it takes for gut changes to translate into steadier symptoms.
Is this hormone replacement therapy?+
No. There are no synthetic hormones, no bioidentical hormones, and no hormone analogues in this formula. It doesn't add estrogen to your body. It supports the gut bacteria that regulate how your body handles the estrogen and plant compounds you already have.
Can I take it alongside HRT or other menopause treatments?+
Many women do, since it works through a different mechanism than hormone therapy. It's hormone-free, so there's no direct overlap. Talk to the provider managing your treatment before adding anything new, as you should with any supplement.
I'm in perimenopause, not full menopause yet. Is this for me?+
Yes. It's formulated for every stage, from cycling years through perimenopause, menopause and beyond. The estrobolome's role shifts as your ovarian production declines, but it is relevant at every point along that curve.
Will this help my hot flashes specifically?+
We won't promise that for any individual. What the research shows is an association between gut bacteria that produce equol from plant compounds and milder hot flashes in some studies, which is part of why this formula targets the estrobolome. Many women tell us sleep and night sweats are what they notice most.
Do I need to refrigerate it?+
No. Store it at room temperature, out of direct sunlight. Take one capsule daily with water, with or without food, whatever makes it easiest to remember.
Is it safe with my medication or other conditions?+
It's hormone-free, vegan, third-party tested, and free from nine major allergens. That said, if you're taking medication or managing a medical condition, talk to your healthcare provider before starting, as you should with any new supplement.
Can I cancel my subscription?+
Anytime, from your account, in two clicks. There's no minimum number of orders. You can also skip a shipment or change how often it arrives.
What if it doesn't work for me?+
Email hello@dailynouri.com within 30 days of delivery and we'll arrange a return and full refund. We'd rather you tell us it didn't work than quietly give up on it.
One capsule a day.
Ninety days to feel the difference.
Seven clinically studied strains. 12 billion CFU. Plant-based Ahiflower® Omega 3·6·9. Built for the gut–hormone axis, from perimenopause through menopause and beyond.
Save 15% on your first order · Free shipping on subscriptions · Cancel anytime
References
- Plottel CS, Blaser MJ. Microbiome and Malignancy. Cell Host & Microbe. 2011;10(4):324–335.
- Ervin SM, Li H, Lim L, et al. Gut microbial β-glucuronidases reactivate estrogens as components of the estrobolome. Journal of Biological Chemistry. 2019;294(49):18586–18599.
- Baker JM, Al-Nakkash L, Herbst-Kralovetz MM. Estrogen-gut microbiome axis: Physiological and clinical implications. Maturitas. 2017;103:45–53.
- Setchell KD, Cole SJ. Method of defining equol-producer status and its frequency among vegetarians. Journal of Nutrition. 2006;136(8):2188–2193.
- Franco OH, Chowdhury R, Troup J, et al. Use of Plant-Based Therapies and Menopausal Symptoms: A Systematic Review and Meta-analysis. JAMA. 2016;315(23):2554–2563.
- Freeman EW, Sammel MD, Sanders RJ. Duration of menopausal hot flashes and associated risk factors. Menopause. 2014;21(9):924–932.
- Mauvais-Jarvis F, Clegg DJ, Hevener AL. The role of estrogens in control of energy balance and glucose homeostasis. Endocrine Reviews. 2013;34(3):309–338.
- Greendale GA, Sternfeld B, Huang M, et al. Changes in body composition and weight during the menopause transition. JCI Insight. 2019;4(5):e124865.
- Kadooka Y, Sato M, Imaizumi K, et al. Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial. European Journal of Clinical Nutrition. 2010;64(6):636–643.
Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease, and it is not hormone replacement therapy. Cited research describes studies of individual compounds, strains, species and mechanisms, and is not a study of this finished product; probiotic effects are strain-specific and results from one strain do not transfer to another. Individual results vary. Reviews reflect the experiences of individual customers and are not a guarantee of outcome. Always consult a qualified healthcare provider before starting a new supplement, especially if you are taking medication or managing a medical condition.