A probiotic built for menopause.
One capsule, once daily. Free shipping, 30-day guarantee.
As your ovaries slow down, your gut takes on more of the job of regulating estrogen. Menopause Probiotic ES2 pairs a three-strain blend selected specifically for that job with resveratrol, a plant compound studied for its effect on hot flashes.
- The Floradapt® Menopause Probiotic Blend, three strains selected for the gut-hormone axis in menopause
- Led by L. brevis KABP™-052, chosen for its high beta-glucuronidase activity, the enzyme that recycles estrogen in the gut
- Resveratrol from Polygonum cuspidatum extract, studied in randomized trials for hot flash frequency
- One small capsule a day. No synthetic hormones, no stimulants
Free shipping · 30-day money-back guarantee · The same three-strain blend studied in a 12-week clinical trial for menopause symptoms
What women in menopause are saying.
Game changer!
"I have been taking this since October 2025 & it's been a game changer. It took about 3 weeks to a month for it to start working. I have not had any hot flashes or night sweats since then."
Hot flashes gone!
"This really helps with hot flashes! I was getting so many all day and all night. After taking for a month they have all but disappeared with only the occasional hot flash here and there. It's a lifesaver!"
Don't run out or you will feel it!
"This really works. So happy I found it."
Life-changing
"This product is a game changer. Would buy again."
If these menopause symptoms sound familiar, read on.
Perimenopause and menopause bring on a cluster of changes that feel disconnected, but they are not random. Most are downstream of the same hormonal shift, and that shift is one your gut has a hand in regulating.
Hot flashes that arrive without warning, day or night
Night sweats that break your sleep and soak through the sheets
Sleep that breaks at 2 or 3am and won't restart
Mood swings, irritability or anxiety that feel unlike you
Brain fog and losing your train of thought mid-sentence
Weight gain around the middle, even with no change in diet
Vaginal dryness or discomfort
Joint aches and stiffness that showed up out of nowhere
Periods that have become irregular or unpredictable
These cluster together for a reason. They are downstream of a hormonal shift your gut helps regulate, and that system is one of the few upstream causes you can support daily.
Your gut is an estrogen recycling plant.
There's a specific set of gut bacteria, collectively called the estrobolome, whose job is to decide whether the estrogen your body has already used gets recycled back into circulation or flushed out for good. Here's the loop.1,2
Estrogen does its work
Estradiol travels the body regulating temperature, sleep architecture, bone turnover, skin, mood and vascular tone. In perimenopause, ovarian output starts swinging; after menopause it drops sharply.
The liver packages it for disposal
Used estrogen is conjugated — essentially gift-wrapped with a glucuronic acid tag that marks it "inactive, ready to leave." It exits the liver in bile and lands in the gut.
Gut bacteria hold the key
Certain species produce an enzyme called beta-glucuronidase (GUS). GUS unwraps the package, reactivating that estrogen so it can be reabsorbed through the gut wall and put back to work. No GUS activity, no recycling — it simply leaves.1,2
In menopause, that recycling loop matters more
When the ovaries are producing far less, the estrogen your gut recovers becomes a proportionally bigger share of what's circulating. And menopause itself is associated with a less diverse microbiome and a shifted estrobolome, right when you need it working well.
This is also why the timeline can feel long. Hot flashes and night sweats last a median of more than seven years for many women once they start.6 A system working on that timescale needs daily, consistent support, not a two-week trial.
The clinical evidence behind this exact blend.
245 women, 12 weeks, symptom scores
In a randomized, double-blind, placebo-controlled trial, 245 peri- and postmenopausal women received either this three-strain blend or placebo for 12 weeks. The probiotic group showed a significantly greater improvement in total Menopause Rating Scale (MRS-II) score than placebo, with the strongest effects in hot flashes and sleep disturbance.5
A plant compound studied for hot flashes
In a separate pilot trial, 150 mg/day of resveratrol reduced hot flash frequency by roughly 30% versus placebo over 12 weeks. A broader review of resveratrol trials in menopausal women reported reduced hot flash number and intensity in the majority of patients studied.7,8
Both pieces of this formula have been studied on their own, at the doses and durations described above. Neither claim is a promise about how this specific capsule will perform for you.
This is not hormone replacement therapy. Nothing in this formula adds estrogen or mimics it directly. It supports the bacterial systems that determine how your body handles the estrogen it already has, alongside a plant compound studied for symptom relief.
Built for the gut-hormone axis through menopause. Nothing else in it.
Most menopause supplements lean on herbal blends or bioidentical hormones. Menopause Probiotic ES2 does something different: it targets the specific bacterial mechanism behind estrogen recycling, and pairs it with a plant compound studied for hot flashes.
What each strain is doing
Resveratrol & Ahiflower® Omega 3·6·9
Resveratrol, sourced from Polygonum cuspidatum extract, studied in randomized trials for hot flash frequency and intensity. Paired with 265 mg of plant-based Ahiflower® Omega 3·6·9 to support a healthy inflammatory response in the gut.7,8
No fish, no fillers. One capsule a day, with or without food.
Other ingredients: Ahiflower® (Buglossoides arvensis) seed oil, vegetable cellulose (capsule), dicalcium phosphate, stearic acid (vegetable), silica, magnesium stearate (vegetable). 30 capsules per bottle, a 30-day supply.
No powders. No protocol. One capsule.
No estrogen, no progesterone, no phyto-blend guesswork. It works on your own estrogen metabolism.
Designed to complement, not replace. Run it by your provider if you're on hormone therapy.
With food or without. Shelf-stable: no refrigeration, no dosing schedule to track.
Pay with pre-tax dollars. Free US shipping on every order.
Choose 1-, 3- or 6-bottle delivery. Change it yourself in two clicks.
If it isn't doing anything for you, tell us and we'll refund it.
Give it a full cycle of your gut, not a weekend.
Probiotics work by shifting an ecosystem. Most women notice changes somewhere between week 4 and week 12, which lines up with the 12-week window the clinical trial behind this blend used.
Settling in
The strains begin establishing. Digestion and bloating are usually the first things to move. No loading phase, no timing rules: one capsule, any time of day.
Nights get quieter
This is where most women report the shift they came for: fewer night sweats, fewer wake-ups, and sleep that holds. Daytime flashes often start easing alongside it.
The compounding part
Steadier mood and energy, better skin and digestion — the downstream effects of sleeping through the night again and of an estrobolome that's being supported daily.
Give it 12 weeks. Hot flashes and night sweats can persist for years once they start.6 That long runway is exactly why the clinical research behind this formula ran for a full three months, not a few days.
Clinicians on the gut-hormone connection.
"As an Integrative Reproductive Endocrinologist, I see the profound impact hormones have on people's lives every day. I am so excited there is now a probiotic that focuses on the foundational role the gut microbiome has on hormone regulation."
"So exciting to have an everyday probiotic that actually supports women's health. The gut has endocrine inputs and outputs that regulate so much, from menstrual cycles and weight to immune function and mood."
Start supporting your menopause today.
Every option is the same formula: one capsule, 1 billion CFU, resveratrol, 265 mg Ahiflower®. The only difference is how many bottles ship. Price and any savings are shown at checkout.
1 bottle
- Try it for a full month
- Free shipping
- 30-day money-back guarantee
3 bottles
- The full window the clinical research used
- Never run out mid-transition
- Free shipping
- 30-day money-back guarantee
6 bottles
- Six months, one decision
- Free shipping
- 30-day money-back guarantee
Also available on Amazon. Prices shown at checkout in USD.
Try it without the risk
If Menopause Probiotic ES2 isn't right for you, contact us at hello@dailynouri.com within 30 days of delivery and we'll send a prepaid return label and refund you in full.
Menopause questions women ask us most
How long until I notice a difference?+
Digestion often settles first, within the first two weeks. Sleep and hot flash frequency usually take longer, and the clinical trial behind this blend measured its results at the 12-week mark. That is the window we ask you to judge it by.
What is resveratrol and why is it in this formula?+
Resveratrol is a plant polyphenol, sourced here from Polygonum cuspidatum extract. It has been studied in randomized, placebo-controlled trials for its effect on hot flash frequency and intensity in menopausal women.
Is this hormone replacement therapy?+
No. There are no synthetic hormones, no bioidentical hormones, and no hormone analogues in this formula. It doesn't add estrogen to your body. It supports the gut bacteria that regulate how your body recycles the estrogen it already has.
Can I take it alongside HRT or other menopause treatments?+
Many women do, since it works through a different mechanism than hormone therapy. It's hormone-free, so there's no direct overlap. Talk to the provider managing your treatment before adding anything new, as you should with any supplement.
I'm in perimenopause, not full menopause yet. Is this for me?+
Yes. The clinical research behind this blend included both peri- and postmenopausal women. The estrobolome's role matters at every point along that transition, not just after your final period.
Will this help my hot flashes specifically?+
We won't promise that for any individual. In the clinical trial behind the probiotic blend, hot flashes and sleep disturbance showed the strongest improvement of any symptom measured. Resveratrol has separately been studied for hot flash frequency. Individual results vary.
Do I need to refrigerate it?+
No. Store it at room temperature, out of direct sunlight. Take one capsule daily with water, with or without food.
Is it safe with my medication or other conditions?+
It's vegan, third-party tested, and free from nine major allergens. That said, if you're taking medication or managing a medical condition, talk to your healthcare provider before starting, as you should with any new supplement.
What if it doesn't work for me?+
Email hello@dailynouri.com within 30 days of delivery and we'll arrange a return and full refund.
One capsule a day.
Twelve weeks to judge it properly.
The Floradapt® Menopause Probiotic Blend, led by L. brevis KABP™-052. Plus resveratrol and 265 mg Ahiflower® Omega 3·6·9. Built for the gut-hormone axis through menopause.
Free shipping · 30-day money-back guarantee
References
- Plottel CS, Blaser MJ. Microbiome and Malignancy. Cell Host & Microbe. 2011;10(4):324–335.
- Ervin SM, Li H, Lim L, et al. Gut microbial β-glucuronidases reactivate estrogens as components of the estrobolome. Journal of Biological Chemistry. 2019;294(49):18586–18599.
- Kaneka Probiotics & AB-Biotics. Strain screening of 84 candidate strains across 16 species for beta-glucuronidase (GUS) activity, identifying Levilactobacillus brevis KABP-052 as the lead strain. As reported in NutraIngredients, 2024.
- Randomized, double-blind, placebo-controlled trial of L. brevis KABP-052, L. plantarum KABP-051 and P. acidilactici KABP-021 in 111 peri- and postmenopausal women: significantly higher estradiol and estrone after 12 weeks versus placebo. As reported in NutraIngredients, 2024.
- Randomized, double-blind, placebo-controlled trial of the same three-strain blend in 245 peri- and postmenopausal women: significant improvement in Menopause Rating Scale (MRS-II) score, with the strongest effects in hot flushes and sleep disturbance, over 12 weeks. Published in The Journal of The Menopause Society, 2026.
- Freeman EW, Sammel MD, Sanders RJ. Duration of menopausal hot flashes and associated risk factors. Menopause. 2014;21(9):924–932.
- Li H, Wang J, Song Y, et al. Resveratrol supplementation and hot flashes: a systematic review and meta-analysis of randomized controlled trials.
- New Perspectives on the Use of Resveratrol in the Treatment of Metabolic and Estrogen-Dependent Conditions Through Hormonal Modulation and Anti-Inflammatory Effects. Current Issues in Molecular Biology. 2025. (Randomized, double-blind study reporting reduced hot flash number and intensity in 78.6% of patients studied.)
Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease, and it is not hormone replacement therapy. Cited research describes studies of the strain blend and of resveratrol individually, not necessarily of this exact finished capsule; results are not a guarantee of outcome for any individual. Reviews reflect the experiences of individual customers. Always consult a qualified healthcare provider before starting a new supplement, especially if you are taking medication or managing a medical condition.