The support system your hormones have been waiting for.
In perimenopause, estradiol stops tapering and starts swinging, and the gut bacteria that clear it are shifting at the same time. Hormone Balance Probiotic ES1 is the daily probiotic built for that loop.
Hormone Balance Probiotic ES1
The daily probiotic that supports clearing estrogen, the exact part of the loop perimenopause destabilizes.
The ritual women keep.
Waited a month before I posted a review. I'm 42, very active, however needed something to help with weight gain, and energy. Already on my second body, lost 3 lbs and feel great.
This is my first time ever taking any supplement/ vitamins, and I will be 48 soon. I have always had problems with sleep, and now that I'm in perimenopause it's been so much worse. I started these a month ago and for the first time in my life I am sleeping great! The whole night through! I also feel better through out the day. The only regret I have is not starting these sooner!!!
This always works when I feel like I'm out of balance….if that makes sense. A woman's best friend for perimenopause
Six changes women experience and how Hormone Balance Probiotic ES1 supports each
Perimenopause can start in your late thirties and run four to eight years before your final period. These are the changes women describe most, and the part of the gut-hormone loop ES1 is built to support.
Supports healthy estrogen metabolism through the estrobolome, so estrogen is cleared rather than over-recirculated while your own production swings.
Pediococcus acidilactici KABP™-021 and Lactiplantibacillus plantarum KABP™-051 support everyday digestive comfort and regularity while building gut diversity.
Lactobacillus gasseri KABP™-064 is a cornerstone estrobolome strain also studied for metabolic and weight support.
Supports a steadier gut-hormone connection day to day. The gut has endocrine inputs and outputs that reach far past digestion.
Lacticaseibacillus rhamnosus SP1 is studied along the gut–skin axis, complementing the estrogen metabolism support the rest of the blend provides.
Levilactobacillus brevis KABP™-052 reinforces the gut–immune interface and a balanced vaginal microbiome, part of the whole female-microbiome picture.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Support the loop underneath all six.
One capsule daily, built for the years your estrogen stops behaving predictably.
Get Started →In perimenopause, your gut has more to say about estrogen than ever. That's the estrobolome.
The estrobolome is the collection of gut bacteria that metabolize and regulate estrogen. It is the control point for how much estrogen is reabsorbed versus eliminated. As ovarian output turns erratic, that control point matters more than it ever has. Hormone Balance supports it at the root.
In perimenopause estradiol spikes and drops instead of tapering. Whatever your body makes still ends up in the gut to be cleared.
Estrobolome bacteria express β-glucuronidase, deciding what gets reabsorbed back into circulation versus eliminated. This is the part of the loop your ovaries don't set.
Hormone Balance supports the microbes that keep estrogen recycling in a healthy range, daily, all the way through the transition.
This is where the estrobolome lives.
Sectioned and stained, the intestinal mucosa reveals the crypts and villi that house your gut microbiota. Here, along the lower-GI epithelial lining, estrobolome bacteria express β-glucuronidase, the enzyme that decides how much estrogen is reabsorbed versus eliminated. It is the one part of the perimenopausal picture you can support every day.
One capsule, support through the transition.
Supports the estrobolome to metabolize and clear estrogen.
Helps steady the hormonal ups and downs as cycles become shorter, heavier, or less predictable.
A balanced gut shows up on your skin: calmer, clearer, more even.
Nurtures a diverse, resilient microbiome. The bloating and irregularity that arrive with perimenopause start here.
Benefits that build, week by week.
The estrobolome responds to consistency, not to a two-week trial. Here's what daily use supports across your first 90 days and beyond.
- The seven strains reach the lower gut, where estrogen is metabolized
- Estrobolome-active species begin to establish
- Bloating and irregularity start to ease
- β-glucuronidase activity moves toward a healthy range
- Less estrogen recycled back into circulation
- Steadier energy and mood through the swings
- Cycles feel less erratic month to month
- Skin looks calmer and more even
- The perimenopausal peaks and dips soften
- Microbial diversity continues to build
- The gut side of estrogen balance is established
- The same window most probiotic studies run
- A resilient estrobolome, maintained daily
- Ongoing estrogen metabolism support
- Carries from perimenopause into menopause
Clinically studied strains, built for the gut-hormone connection.
A targeted blend of clinically studied probiotic strains, chosen for the gut-hormone connection and the years it's under the most strain, delivered in one capsule-in-capsule dose a day.
A cornerstone estrobolome strain: it helps keep β-glucuronidase activity in a healthy range, so estrogen is metabolized and cleared rather than over-recirculated through the gut. Also studied for metabolic and weight support.
Works across the estrobolome to crowd out less favorable bacteria and build a diverse, resilient gut community, the foundation that healthy estrogen metabolism depends on. Human-studied alongside IMC-502®.
Paired with IMC-501® to reinforce the gut lining where the estrobolome lives, supporting a strong intestinal barrier and calm, comfortable digestion, keeping the niche favorable for estrogen-regulating microbes.
Supports estrogen metabolism through the estrobolome while reinforcing the gut–immune interface and a balanced vaginal microbiome, part of the whole female-microbiome picture that shifts in perimenopause.
Supports estrogen metabolism by keeping the gut environment stable and favorable for estrobolome activity. A robust, acid-tolerant strain that also eases bloating and maintains regularity.
Supports estrogen metabolism by nourishing gut-lining diversity and short-chain fatty acid production, one of the most-studied and hardiest probiotic species.
Studied along the gut–skin axis: it complements estrogen metabolism support and the clearer, more even skin that comes with a balanced estrobolome.
Not a probiotic. The plant-based omega oil that forms the protective outer capsule. Rich in stearidonic acid (SDA), a highly convertible omega-3 that supports whole-body inflammatory balance while shielding the live cultures on their way to the gut.
A capsule, inside a capsule.
Most probiotics lose potency before they ever reach your gut. Our capsule-in-capsule design seals the live cultures inside a protective second shell, so they survive the journey and release where they actually work.
The protective outer shell shields delicate strains from harsh stomach acid.
Delayed release delivers cultures to the lower gut, where the estrobolome lives.
More strains arrive alive and active, a key reason it's twice as effective.
What the experts say.
“As an Integrative Reproductive Endocrinologist, I see the profound impact hormones have on people's lives every day. I am so excited there is now a probiotic that focuses on the foundational role the gut microbiome has on hormone regulation and its downstream effects: metabolism, skin, mood, and fertility.”
“So exciting to have an everyday probiotic that actually supports women's health. The gut has endocrine inputs and outputs that regulate so much, from menstrual cycles and weight to immune function and mood. Women deserve a high-quality probiotic that promotes balance by acting at the intersection of the gut-brain axis.”
“I'm thrilled to be part of Daily Nouri's launch of our new hormone balance probiotic! By emphasizing the importance of nutrition and the role of gut health in hormone regulation, Daily Nouri empowers women to feel their best every day.”
One small capsule. One system, steadied.
Good questions, straight answers.
01What exactly is the estrobolome?
02Why does the estrobolome matter more in perimenopause?
03How is this different from a regular probiotic?
04I'm still getting my period. Is it too early to start?
05Can I take it alongside HRT?
06When will I notice a difference?
07Is it safe to take long-term, through menopause and beyond?
08How do I take it, and how long does a bottle last?
Give your estrobolome a daily ally.
Hormone Balance Probiotic ES1. 30 capsules, one a day. Save up to 20%, free shipping, cancel anytime.
Get Started →