A probiotic built for hormonal weight gain.
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If the weight arrived around your middle without your habits changing, the problem is not willpower. Estrogen decides where your body stores fat and how well it handles insulin, and your gut bacteria decide how much estrogen you keep. That system is called the estrobolome, and Hormone Balance ES1 is the daily probiotic built to support it.
- Works on the estrobolome, the gut bacteria that regulate estrogen clearance
- 7 clinically studied strains, 12 billion CFU, for the gut–hormone–metabolism axis
- Includes L. gasseri, the most researched probiotic species for abdominal fat
- One small capsule a day. No stimulants, no diuretics, no hormones, nothing to count
Free shipping on subscriptions · Cancel anytime · Shared by 1,400+ clinicians including OB/GYNs
What women say about weight, bloat and energy.
Amazing
"Waited a month before I posted a review. I'm 42, very active, however needed something to help with weight gain, and energy. Already on my second body, lost 3 lbs and feel great."
Very happy
"I've been taking it everyday for about 2 weeks now & have noticed my bloat has decreased, I'm about a inch smaller in my waist (swear) … for me this has def helped with hormonal odor, weight/water retention, gut & all over wellness. I subscribed monthly to save a few bucks since I see myself taking this long term consistently."
Wonderful
"As someone who has pcos this product has been so helpful with regulating my hormones. I feel more energized, less anxious, and happier. I have been losing weight easier than before and my acne has been improving. I never thought a supplement could help this much. Thank you Daily Nouri, I hope these results don't go away."
It works!! :)
"I waited a few days to try and see the effects of this product. I am on day 5 and I can honestly say it works. Like the rest of the reviews, I've noticed a decrease in bloating (something I've struggled with), It makes me go to the bathroom daily and overall feel great. In terms of the hormones, I'm sure it'll take more time for me to see results but I do feel like a weight has been lifted of my body. Highly recomment!!!"
If any of these sound like you, read on.
Nothing about how you eat or move has changed. The weight came anyway, and it landed somewhere it never used to. Most women are told to eat less and try harder. The pattern is the point: weight that moves with your cycle and settles at your waist is following your hormones, not your discipline.
Weight that has settled around your middle, when it used to go to your hips and thighs
The same diet and the same workouts, and the scale creeping up anyway
Bloating and water retention that spike in the week before your period
Two to five pounds that appear premenstrually and never fully leave
Sugar and carb cravings that arrive on a schedule, not at random
Flat energy in the afternoon, and a crash you plan your day around
PMS, breast tenderness and mood shifts that track with your cycle
Constipation or IBS-like patterns that worsen premenstrually
Sleep that breaks at 3am, night sweats, or hot flashes
You've done the deficit, the fasting and the training block, and it keeps returning
These cluster together for a reason. Your body composition is downstream of a hormone your gut helps regulate, and it is one of the few upstream causes you can actually work on daily.
Weight is downstream of hormones. Hormones are downstream of your gut.
Estrogen is not only a reproductive hormone. It is a metabolic one. Estrogen receptors sit in fat tissue, muscle, liver and the hypothalamus, where they help govern insulin sensitivity, energy expenditure and where on your body fat is stored.4 When that signalling shifts, your body does not just gain weight. It gains it somewhere new.
The estrobolome is the group of gut bacteria that metabolize estrogen. First named in peer-reviewed science in 2011, it decides how much used estrogen gets recirculated back into your body versus cleanly excreted.1
Your liver tags used estrogen for removal
Once estrogen has done its job, the liver marks it "spent" through glucuronidation and sends it to the gut for elimination.
Your gut bacteria decide what happens next
Bacteria in the estrobolome produce beta-glucuronidase, which can cut that tag back off, reactivating the estrogen and returning it to circulation instead of letting it leave.2
Your body composition reads the result
Estrogen signalling helps set insulin sensitivity and fat distribution. When it drifts, fat shifts from the hips and thighs toward the abdomen, and the same calories stop behaving the same way.3,4
This is why the change so often feels sudden. In the SWAN cohort, fat mass began accelerating roughly two years before the final menstrual period and continued for about two years after, while lean mass declined over the same window.5 The habits did not change. The hormonal context did.
Two routes run from your gut to your waistline.
The estrogen route
A gut microbiome low in diversity, or skewed toward high beta-glucuronidase activity, changes how much estrogen is reabsorbed rather than excreted. Researchers describe this as the estrogen–gut microbiome axis, and link its disruption to conditions that include metabolic syndrome and obesity.3
Because estrogen governs fat distribution and insulin sensitivity, a gut that mishandles estrogen clearance has a direct line to where you store weight.4
The barrier route
A compromised intestinal barrier lets bacterial fragments called lipopolysaccharide cross into the bloodstream. This low-grade state, named metabolic endotoxemia, is enough on its own to trigger insulin resistance, inflammation and fat gain in controlled research.6
Insulin resistance and estrogen dysregulation then feed each other: visceral fat is itself hormonally active, producing enzymes that alter the estrogen balance that put it there.
Both routes point at the same place. Gut composition differs measurably between lean and obese individuals, and shifts as body composition changes,7 which is why the microbiome is now treated as a metabolic organ rather than a digestive detail.
This is not a diet mechanism. Nothing here suppresses appetite or drains water weight. It works on the system that decides what your body does with the hormones and the calories you already have.
Why twelve weeks is the number that matters.
Two things in this field are measured in weeks, not days. The first is colonization: a probiotic has to establish itself before it can change anything, and that is dose- and time-dependent. The second is body composition, which moves on a monthly hormonal rhythm layered on top. Put together, the randomised trials that have found metabolic effects from probiotic supplementation ran for twelve weeks, not two.
L. gasseri, twelve weeks, visceral fat area
L. gasseri is the most studied probiotic species for abdominal adiposity, and it is in this formula. In a 12-week randomised controlled trial in adults with obese tendencies, supplementation was associated with a reduction in visceral fat area versus control.8 Strains within a species are not interchangeable, so we cite that as species-level context rather than a claim about this bottle.
The estrobolome is the target, not the scale
The peer-reviewed work on the estrogen–gut microbiome axis is what this formula is built around: bacteria that regulate how much estrogen you clear, and a gut barrier whose integrity governs the inflammation that undermines insulin sensitivity.3,6 Both are systems you support daily, and neither responds to a single bottle.
Judge it at 90 days. That is not a sales frame, it is the timescale the research uses. It is also why our best-value option is a full 90-day supply rather than a trial size.
A closer look at Hormone Balance ES1.
Built for the gut–hormone–metabolism axis. Nothing else in it.
Most weight supplements borrow from the stimulant aisle: caffeine to blunt appetite, a diuretic to move the scale for a week. Hormone Balance ES1 has neither. It works on the bacterial system your hormones and your metabolism both depend on.
The 7-strain probiotic complex
Seven clinically studied strains selected for women's gut–hormone health, including L. gasseri and L. rhamnosus, the two species with the most metabolic research behind them.
Ahiflower® Omega 3·6·9
A plant-based seed oil rich in SDA, GLA and ALA, included to support a healthy inflammatory response in the gut. That matters here because barrier integrity is route two: a leaky gut drives the low-grade inflammation that undermines insulin sensitivity.6
No fish, no fillers, no aftertaste. Citrus-scented capsules, one a day, with or without food.
Metabolism moves on cycle time, not overnight.
This is the part most people get wrong. A probiotic is not a cleanse and it is not a diet pill. Colonization is dose- and time-dependent, and hormones work on a monthly rhythm on top of that. The randomised research in this field measured at 12 weeks for a reason. Here is the arc most women describe.
Bloat and digestion settle first
The gut responds fastest. Less bloating, less water retention, more regular digestion. Waistbands often ease before the scale moves at all, and that is expected rather than disappointing.
The premenstrual swing softens
One to two full cycles in is where women most often notice it: less premenstrual water weight, steadier cravings in that week, and an afternoon that no longer ends in a crash.
The compounding window
This is the window the research used. Steadier energy, a month that stops swinging, and the sense that your body is responding to your effort again instead of resisting it.
Consistency beats intensity. One capsule, every day, for 90 days. Missing a few days will not undo your progress, but starting and stopping every two weeks means you never reach the window where the research found results. That is why our best-value option is a full 90-day supply.
1,400+ clinicians, including OB/GYNs, share it with patients.
"As an Integrative Reproductive Endocrinologist, I see the profound impact hormones have on people's lives every day. I am so excited there is now a probiotic that focuses on the foundational role the gut microbiome has on hormone regulation."
"So exciting to have an everyday probiotic that actually supports women's health. The gut has endocrine inputs and outputs that regulate so much, from menstrual cycles and weight to immune function and mood."
Start today. Cancel anytime.
Every option is the same formula: one capsule, 12 billion CFU, 265 mg Ahiflower®. The only difference is how long you commit and how much you save. 15% off your first order applies automatically to all three, no code to remember.
Monthly
- Try it for one full cycle
- Free shipping, every order
- Change frequency, skip or cancel anytime
3-month supply
- The full 12-week window the research used
- Never run out mid-cycle
- Free shipping, every order
- Skip or cancel anytime
6-month supply
- Lowest per-day price we offer
- Six months, one decision
- Free shipping, every order
Also available on Amazon. Prices shown at checkout in USD.
Try it without the risk
If Hormone Balance isn't right for you, contact us at hello@dailynouri.com within 30 days of delivery and we'll send a prepaid return label and refund you in full. Subscriptions have no minimum. Change your delivery frequency, skip a month, or cancel in two clicks from your account.
Questions women ask us most
How long until I notice a difference?+
Bloating and water retention often ease first, within the first two weeks. Cycle-related changes usually take one to two full cycles, roughly 30 to 60 days. The randomised trials in this field measured their endpoints at 12 weeks. If you are going to judge it, judge it at 90 days.
Is this a weight loss supplement?+
No, and we won't pretend otherwise. There is no stimulant, no appetite suppressant and no diuretic in this bottle. It supports the gut–hormone system that influences where your body stores fat and how it handles insulin. That is an upstream input, not a shortcut, and it works alongside how you eat, move and sleep rather than instead of it.
Why has my weight moved to my middle?+
Estrogen helps determine fat distribution. While estrogen signalling is robust, women preferentially store fat in the hips and thighs. As it shifts, storage moves toward the abdomen and visceral depots, and insulin sensitivity typically declines with it. In the SWAN cohort, fat mass began rising about two years before the final menstrual period. It is a change in hormonal context, not in your discipline.
Will I lose weight without changing anything else?+
We can't promise that, and anyone who does is selling you something. What this does is work on the system underneath: estrogen clearance and gut barrier integrity. Many women tell us bloat and water retention ease first, and that effort starts producing results again. That is the honest version.
I have PCOS. Is this relevant to me?+
PCOS involves insulin resistance and androgen excess, and research increasingly implicates gut microbiome composition in both. This is not a PCOS treatment and does not replace anything your doctor has prescribed. It supports the estrobolome and gut barrier, which is why PCOS is one of the most common reasons women tell us they started.
Can I take it alongside a GLP-1 medication?+
Many customers do, and a daily probiotic is a common companion to GLP-1 therapy given how often it comes with digestive side effects. It is hormone-free and stimulant-free, so there is no overlap of mechanism. Clear it with the provider managing your prescription first, as you should with any supplement.
Does it contain stimulants or diuretics?+
Neither. No caffeine, no stimulants, no diuretics, no synthetic hormones, no hormone analogues, no soy isolates. Diuretics move the number on the scale for a week by moving water. That is not what this is for.
How is this different from the probiotic I already take?+
Most probiotics are built for digestion, with strains chosen for gut comfort. Hormone Balance ES1 uses seven strains selected for the gut–hormone axis and pairs them with Ahiflower® Omega 3·6·9 for the intestinal barrier. Different job, different formula.
Can I take it in perimenopause or after menopause?+
Yes, and it is built for it. The menopause transition is exactly when fat redistribution and insulin sensitivity shift most, while the estrobolome's role in clearing estrogen keeps mattering. Many women find this is the window where they feel the difference most.
Do I need to refrigerate it?+
No. Store it at room temperature, out of direct sunlight. Take one capsule daily with water, with or without food, whatever makes it easiest to remember.
Is it safe with my medication, or if I'm pregnant?+
It's hormone-free, vegan, third-party tested, and free from nine major allergens. That said, if you're pregnant, breastfeeding, or taking medication, talk to your healthcare provider before starting, as you should with any new supplement.
What if it doesn't work for me?+
Email hello@dailynouri.com within 30 days of delivery and we'll arrange a return and full refund. We'd rather you tell us it didn't work than quietly give up on it.
The four foods that do the most work with it.
A probiotic supports the bacteria you have. What you eat decides what those bacteria have to work with. Neither substitutes for the other, and the women who tell us the difference was obvious are almost always doing both. None of this requires a diet, a deficit or an app.
Fiber is the single highest-leverage change. Most American women eat roughly half the recommended 25 grams a day. Fiber feeds the bacteria that keep the gut barrier intact, and it binds spent estrogen in the gut so it leaves rather than being reabsorbed.
Cruciferous vegetables
Broccoli, cauliflower, cabbage, Brussels sprouts, kale. They supply glucosinolates, precursors to compounds the liver uses in the first phase of estrogen metabolism, alongside a meaningful fiber load.
Practically: one serving most days. Roasted, or shredded raw into a slaw.
Ground flaxseed
The richest common dietary source of lignans, plant compounds your gut bacteria convert into weak estrogen-modulating metabolites. It has to be ground; whole seeds pass through largely intact.
Practically: one to two tablespoons daily into yoghurt, oats or a smoothie. Keep it in the fridge.
Fermented foods
Yoghurt with live cultures, kefir, sauerkraut, kimchi, miso. Controlled research has linked a high-fermented-food diet to greater microbiome diversity and lower inflammatory markers.
Practically: a small daily portion beats a large weekly one. This complements the capsule rather than replacing it.
Protein at breakfast
Thirty grams in your first meal blunts the glucose swing that drives the mid-afternoon crash and the cravings behind it. It also protects the lean mass that declines through the menopause transition.5
Practically: eggs, Greek yoghurt, cottage cheese or a shake. Before coffee, not after.
Two things worth subtracting, too. Alcohol competes for the same liver pathways that clear estrogen and reliably degrades sleep quality, which is its own metabolic input. Ultra-processed food displaces fiber and, in controlled feeding research, leads people to eat several hundred more calories a day without noticing. Neither has to be zero to matter.
Start with fiber and the capsule. If you change one thing this week, get closer to 25 grams of fiber a day and take it every morning. The rest of this list can wait until that is a habit.
One capsule a day.
Ninety days to judge it properly.
Seven clinically studied strains built around the estrobolome, the gut bacteria that regulate estrogen clearance. 12 billion CFU. Plant-based Ahiflower® Omega 3·6·9. No stimulants, no diuretics.
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References
- Plottel CS, Blaser MJ. Microbiome and Malignancy. Cell Host & Microbe. 2011;10(4):324–335.
- Ervin SM, Li H, Lim L, et al. Gut microbial β-glucuronidases reactivate estrogens as components of the estrobolome. Journal of Biological Chemistry. 2019;294(49):18586–18599.
- Baker JM, Al-Nakkash L, Herbst-Kralovetz MM. Estrogen-gut microbiome axis: Physiological and clinical implications. Maturitas. 2017;103:45–53.
- Mauvais-Jarvis F, Clegg DJ, Hevener AL. The role of estrogens in control of energy balance and glucose homeostasis. Endocrine Reviews. 2013;34(3):309–338.
- Greendale GA, Sternfeld B, Huang M, et al. Changes in body composition and weight during the menopause transition. JCI Insight. 2019;4(5):e124865.
- Cani PD, Amar J, Iglesias MA, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007;56(7):1761–1772.
- Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Microbial ecology: human gut microbes associated with obesity. Nature. 2006;444(7122):1022–1023.
- Kadooka Y, Sato M, Imaizumi K, et al. Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial. European Journal of Clinical Nutrition. 2010;64(6):636–643.
Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease, and it is not a weight loss product. Cited research describes studies of individual probiotic strains, species and mechanisms, and is not a study of this finished product; probiotic effects are strain-specific and results from one strain do not transfer to another. Individual results vary. Reviews reflect the experiences of individual customers and are not a guarantee of outcome. Always consult a qualified healthcare provider before starting a new supplement, especially if you are pregnant, breastfeeding, taking medication, or managing a medical condition.